The Shrine's charitable arm is the Shriners Hospitals for Children, a network of twenty-two hospitals in the United States, Mexico and Canada. It was originally formed to treat young victims of polio, but as that disease was controlled, they broadened their scope. They now deal with orthopedic care, burn treatment, cleft lip and palate care and spinal cord injury rehabilitation. All treatment offered at Shriner's Hospitals for Children is offered without any financial obligation to patients and their families, and there is no requirement for religion, race, or relationship to a Shriner. Patients must be under the age of eighteen and treatable.
On March 27, 2013, Shriners Hospitals for Children — Twin Cities (SHC-TWI) announced it is a member of the Mayo Clinic Care Network (MCCN).